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KMID : 0370220050490030193
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Yakhak Hoeji
2005 Volume.49 No. 3 p.193 ~ p.197
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HPLC Determination and Pharmacokinetic Profile of Procainamidein Korean Subjects
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장진규/Chang JK
김천석/노길봉/조병구/Kim CS/Nho KB/Cho BG
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Abstract
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Procainamide is the drug of second choice (after lidocaine) in most coronary care units for the treatment of sustained ventricular arrhythmias associated with acute myocardial infarction. The purpose of this study was to develop the efficient assay method of procainamide in human plasma and to assess the pharmacokinetic profile of procainamide in healthy Korean volunteers. The pharmacokinetics of procainamide administered orally was evaluated after a dose of 250 mg. Procainamide in plasma was assayed using a specific HPLC method with UV absorbance at 275nm. AUC was 4.58±0.90 μg/ml.hr, Cmax 1.34±0.39 μg/ml, Tmax 1.06±0.34 hr and half-life 3.07±0.34 hr. Tmax was slightly shorter than that in Caucasian (1~2hr), whereas the half-life was similar to that in Caucasian (2.5~4.1 hr).
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